A non-clinical and clinical IUCLID database dashboard for pharmaceuticals
Access structured toxicological data across study types with the help of the US FDA's toxicity dashboard's data visualisation tools. The dashboard simplifies and enables accurate correlation and concordance analyses by effectively harnessing both animal and human data, and it is designed to aid in the development of advanced predictive toxicological models including QSARs.
Further, it can be used to improve the integrity of industrial chemical regulatory systems in the context of New Approach Methodologies (NAMs), Integrated Approaches to Testing and Assessment (IATAs), Classification, Labelling, and Packaging (CLP), and Adverse Outcome Pathways (AOPs). Furthermore, the information can be used as a powerful tool to predict pharmaceutical attrition rates in pipeline drug development, detect early adverse reactions, and prevent clinical trial failures.
Reference: Evangelisti et al. A non-clinical and clinical IUCLID database for 530 pharmaceuticals (part I): Methodological aspects of its development. Regulatory Toxicology and Pharmacology, 2023, 105416. https://doi.org/10.1016/j.yrtph.2023.105416 530
New drug applications (NDAs)
6021
Non clinical studies
113477
Annotated non-clinical effects
3414
Unique ontological terms
566
Reference substances
15652
Adverse reactions from standard product labels (SPLs)
Drug data
Molecolar weight distribution
Most common pharmacological class
Browse NDAs
| Name |
|---|
| NDA016608-carbamazepine |
| NDA017558-glycopyrrolate |
| NDA017970-tamoxifen citrate |
| NDA018998-enalapril maleate |
| NDA019386-esmolol hydrochloride |
| NDA019922-fenoldopam mesylate |
| More details... |